Want to really improve your longevity? Start by checking in on your cells—specifically, the NAD+ levels in your cells.
Biohacking searches are skyrocketing and more people are experimenting with fasting and immersion therapies to wind back their biological clocks. Though studies support the potentials of intermittent fasting and cold therapy to slow cellular aging and reduce the risk of disease, NAD+ testing as longevity targeting resource has gone largely overlooked—until recently.1,2
What is NAD+?
Nicotinamide adenine dinucleotide, NAD+, is a coenzyme that influences some of the most vital processes in the body, including metabolizing food into energy and regulating cellular processes like DNA repair and immune system functioning.3,4 It acts as a helper molecule throughout the cellular respiration process, resulting in the production of our cell’s most viable energy currency, Adenosine Triphosphate (ATP).5
Though NAD+ plays an essential role in the body’s upkeep, NAD+ levels naturally decrease over time—a reduction that is associated with common aging markers and age-related diseases, including metabolic disorders and neurodegenerative conditions.6
And although we know that a decline in NAD+ levels does occur with age, until recently it’s been hard to determine the velocity of this decline and how it impacts individuals differently.
Intracellular NAD+ testing—which is now available at Hudson Health—offers a clear and personalized view of the current state of your cellular health, and subsequently, insights into potential risk levels for future age-related diseases, including:
- Cardiovascular disease
- Alzheimer’s
- Parkinsons
- Type 2 diabetes
Arming yourself with a baseline analysis is the crucial first step in your NAD optimization journey. From here, you can work with your longevity specialist to implement the best optimization strategies for your body and lifestyle.
As more research around intracellular NAD+ optimization emerges, comprehensive baseline analyses are crucial for supporting their efficacy.
If you’re ready to take your future health into your own hands, schedule your NAD+ test here.
References:
1.Longo VD, Di Tano M, Mattson MP, Guidi N. Intermittent and periodic fasting, longevity and disease. Nat Aging. 2021 Jan;1(1):47-59. doi: 10.1038/s43587-020-00013-3. Epub 2021 Jan 14. PMID: 35310455; PMCID: PMC8932957.
2.Esperland D, de Weerd L, Mercer JB. Health effects of voluntary exposure to cold water – a continuing subject of debate. Int J Circumpolar Health. 2022 Dec;81(1):2111789. doi: 10.1080/22423982.2022.2111789. PMID: 36137565; PMCID: PMC9518606.
3.Cantó C, Menzies KJ, Auwerx J. NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab. 2015 Jul 7;22(1):31-53. doi: 10.1016/j.cmet.2015.05.023. Epub 2015 Jun 25. PMID: 26118927; PMCID: PMC4487780.
4.Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580-020-00313-x. Epub 2020 Dec 22. PMID: 33353981; PMCID: PMC7963035.
5.Xie, N., Zhang, L., Gao, W. et al. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Sig Transduct Target Ther 5, 227 (2020). https://doi.org/10.1038/s41392-020-00311-7
6.Yahyah Aman, Yumin Qiu, Jun Tao, Evandro F. Fang,
Therapeutic potential of boosting NAD+ in aging and age-related diseases,
Translational Medicine of Aging, Volume 2, 2018, Pages 30-37, ISSN 2468-5011,
7. Poljsak B, Kovač V, Milisav I. Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level? Oxid Med Cell Longev. 2020 Dec 12;2020:8819627. doi: 10.1155/2020/8819627. PMID: 33414897; PMCID: PMC7752291.